This patient noticed her left submandibular swelling from 2 years
ago. She had the first OK-432 therapy one and a half years ago at an
hospital in Tokyo area. After the first treatment, her ranula was
disappeared for 6 months. But, 6 moths after, she had small recurrence
. Her reccured submandubular swelling gradually became big. She went to
the doctor who did her first treatment. But, the doctor alredy moved to
another hospital. So, she did not have treatment. She mailed me asking
treatment one month before this treatment.
Left is her MRI. White lesion means fluid
collection. The shape of white lesion is typical for ranula. Right is
aspirated cyst fluid. This is typical for ranula. After aspiration of
8ml cyst fluid, 1 KE of OK-432 suspended with 2 ml of saline was
This is the course of her treatment. The next day, her ranula
swollen and the color of local skin became red. And fever up was observed. One
week after, her ranula was more hardly swollen. But, there was no pain and fever up. This means very good
response. 2 weeks after treatment, her
ranula began to shrink. 6 weeks after treatment, there was no swelling.
There was no recurrence at three months after treatment.
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