Typical course of OK-432 therapy

This the most important poit to understand this therapy.

This is a typical course of OK-432 intracystic injection therapy for plunging ranula. Left: Before treatment. Middle (Left): The day after treatment. Middle (Right): 2 weeks after treatment. Right: 4 weeks after treatment.
The patient is 13 years old girl. She was punctured at her submandibular skin and aspirated cyst fluid, then injected 1 KE of OK-432. The next day, the submandibular skin was swollen and became red and indurated. Local pain and fever (38Ž) was observed for 2 days, and we used analgesics (oral and a suppository) to treat her. The hard submandibular induration gradually decreased in size. One month after, it disappeared completely and there was no scarring.


This patient is 8 years old girl. She was injected 1 KE of OK-432. From the next day to 1 week after OK-432 injection, reactive increased swelling was observed. And, fever up (38.5Ž) was observed for 2 days. Then, the swelling was gradually reduced and disappeared 6 weeks after treatment.

One of the key word of this therapy is "6 weeks". In average, it needs 6 weeks to cure by this method. Another key word is "inflammation". To be effective, post treatment inflammatory reaction is necessary. When treating head & neck cysts by OK-432, air way stenosis must be took care because of temporary inflammatory increased swelling.

8 years old girl. She was injected 1 KE of OK-432. From the next day to 1 week after OK-432 injection, reactive increased hard swelling was observed. And, fever up (39Ž) was observed for 2 days. Then, the swelling was gradually reduced and completely disappeared 6 weeks after treatment.

27 years old woman. She was injected 2 KE of OK-432. From the next day to 1 week after OK-432 injection, reactive increased hard swelling was observed. The color of skin in prominent portion was changed to red because of scratching by clothes and linens. And, fever up (38Ž) was observed for 2 days. Then, the swelling and color change of the skin was gradually reduced and completely disappeared 6 weeks after treatment.

As you could know upper, it needs at least 6 weeks even if the ranula is cured by only one OK-432 therapy. 6 weeks is very long time. I can not remember what I did 6 weeks ago. If the patient needed 3 OK-432 injections, it would sometimes need almost a half year. This therapy requires patience for both patients and dioctors. I think that the power of inflamation and time will cure ranula and other cystic diseases.

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