Supraclavicular lymphangioma  (5)

She came from Tokyo. She had very big supraclavicular lymphangioma. But, her lymphangioma was disappeared by three OK-432 injections. She was treated as an out patient.


I had consultaion from her 3.5 months before she came to me. Left was the pictutre of first consultation. One month before the first consultation, her right lower neck began to swell. At first, she went to her family doctor. The doctor punctured her swelling. Yellowish serous fluid was aspirated. Then, she was sent to a surgeon.  She  had some examinations,  the conclusion was follow up. When I first consulted, I  answerd that lymphangioma was most suspicious and OK-432 must be the best treatment.  One and a haft months after, the central picture was sent. She went many hospitals at Tokyo. All doctor said that surgery is only treatment. After that, she went another hospitals. But, there was no doctor who showed therapy other than surgery. So, she came to me 3.5 months after the first consultation.


These are her MRI of T2 weighted image. By this codition, fluid collection is clearly recognized. White areas were fluid collection (lymphoma). Right was cyst fluid. Yellowish serous fluid and there were many lymphocytes in it.


This is the first OK-432 treatment. 1.5 KE of OK-432 was injected. But, on the next day, there was almost no increasesed swelling and redness. This means poor response. 6 months later, the effect was insufficient.


15 months after the first treatment, the second treatment was performed. This time, however the distance from my clinic to her living place was almost 300 miles, I treated her one day around trip. Also this time, 1.5 KE of OK-432 was injected. The next day, her lymphangioma was swollen and reddened. This was very good response. 1 week after treatment, her lymphangioma was hardly swollen. This was also very good response. 2 weeks after treatment, her lymphangioma began to shrink. 6 weeks after, her right neck swelling became very small. The dose used was 1.5 KE. This was the same as that of the first treatment. This therapy is a inflammatory reaction of patient to penicillin killed bacteria (OK-432). This is immune reaction. So, the reaction of the second treatment usually strong if the dose of OK-432 used was same.


The swelling after the second treatment was very small. But, by MRI, there was definitely fluid collection. So, the third OK-432 treatment was performed 16 weeks after OK-432 injection.The next day, her lymphangioma was swollen and reddened. This was very good response. 1 week after treatment, her lymphangioma was hardly swollen. 2 weeks after treatment, her lymphangioma began to shrink. 6 weeks after, her right neck swelling was completely disappeared.


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