Left: Before Treatment, Right: The next day after
OK-432 injection
Inflammatory reaction after OK-432 injection. Usually, the color of ranula is blue black lucent. Upper right is the next day after OK-432 intracystic injection. The color of ranula turned to be red cloudy and the size was swollen. And, fever up, 38.5 degrees C was also observed. These means that OK-432 induced very strong inflammation.
Left upper: Smears of cyst fluid before
treatment, Right upper: Smears of cyst fluid 18 hours after OK-432
injection
Lower: Proportions of Inflammatory cells:
yellow: Neutrophils, Blue: Monocytes, Purple: Lymphocytes
The level of Interferon ƒÁ " inflammarory cytokine" were 32 pg/ml in cyst fluid of pre-teatment and 618 pg/ml in cyst fluid of post-treatment.
Migration of inflammatory cells into
the cyst after OK-432 injection.
Left
upper is the smear of ranula cyst fluid before treatment. Small
amount of macrophages those are phagocyting liquids are seen.
Right upper is the smear 18 hours after OK-432 injection. There
are many inflammatory cells. Lower is a proportion of inflammatory
cells. Neutrophils were dominant. And, the inflammatory cytokines
such as interferon gamma, Interleukin -1, tumor necrosis factor
are markedly increased. Namely, because of injection of streptococcus,
white blood cells are migrated into the cyst and cause very strong
inflammation. It is obvious that strong
inflammation will induce the reduction of cyst.
This is my image about the effect
of OK-432.
Ranula is saliva leakage
from sublingual gland. OK-432 is like repair puncture spray. If
OK-432 was injected into the cyst, strong inflammation will occur
and some viscous inflammatory products like fibrin was produced.
These inflammatory products will adhere the leakage part and stop
leak. Cyst fluid will be absorbed gradually. If the leakage part
was strongly repaired, ranula will be cured permanently. If saliva
leak will occur again, ranula will recur.
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